Products

CAS Number: 37248-47-8
English Name: Validamycin

Chinese Aliases: Rice Sheath Blight Fungicide; Jinggangmycin; Bailidas; Effective Mycin; Validamycin; Validamycin Technical; Validamycin Standard; Validamycin A in Methanol; Validamycin/Effective Mycin; Validamycin A/Jinggangmycin
Chemical Formula: C20H35NO13
Molecular Weight: 497.49
Density: 1.69±0.1 g/cm³ (Predicted)
Melting Point: 130-135°C
Boiling Point: 813.7±65.0 °C (Predicted)
Specific Rotation: D24 110° (c = 1 in water or pyridine), 92° (c = 1 in DMF)
Flash Point: 445.885°C
Water Solubility: Readily soluble
Vapor Pressure: Negligible at room temperature
Solubility: Soluble in water, methanol, DMF, DMSO; insoluble in acetone, ethanol, and ether.
Refractive Index: 1.689
pKa: 6.0 (at 25℃)
Storage Conditions: 0-6°C
Appearance: Solid

Introduction
Validamycin is an antibiotic produced by actinomycetes, with strong systemic activity. It is easily absorbed by microbial cells and quickly transmitted within them, interfering with and inhibiting their growth and development. It’s a selective antibiotic bactericide, highly effective against rice sheath blight. It can also be used against rice smut, wheat sheath blight, vegetable damping-off and root rot, cotton, bean damping-off, rice small sclerotial disease, and corn large spot disease. It inhibits trehalase activity in plants, insects, and fungi, causing trehalose accumulation in genetically modified plants.

Properties
– The pure product is a white amorphous powder with no definite melting point. Easily soluble in water, soluble in methanol, dioxane, and DMF, slightly soluble in ethanol, and insoluble in acetone, benzene, and petroleum ether. Highly hygroscopic and weakly alkaline. Stable in neutral and mild acidic or alkaline media at room temperature, but decomposes easily in strong acids or bases.
– Formulations mainly include soluble powder and aqueous solutions, with various combined preparations available.

Uses
– Microbial bactericide mainly used to prevent and treat rice sheath blight, with both protective and therapeutic effects. Also used for small sclerotial disease, corn large spot disease, vegetable damping-off and root rot, as well as cotton, beans, and ginseng damping-off. Application methods include spraying, seed coating, and soil drenching. Compatible with pesticides such as dimethoate and chlorpyrifos.